Glucosamine Sulphate ,Chondroitin Sulphate Sodium Used For Osteoarthritis.

How it works

 Glucosamine is a normal constituent of polysaccharide chains of cartilage matrix and synovial fluid glucosaminoglycans. It stimulates the synthesis of physiological glycosaminoglycans and proteoglycans by chondrocytes and hyaluronic acid by synoviocytes. Glucosamine Sulfate also inhibits the activity of cartilagedestroying enzymes such as collagenase and phospholipase A2, as well as the generation of other tissue damaging substances such as superoxide radicals or the activity of lysosomal enzymes that contributes to its mild anti-inflammatory effects. Chondroitin Sulfate Sodium : Chondroitin Sulfate increases the synthesis of cartilage matrix components such as hyaluronic acid and proteoglycans and reduces the degradation of cartilage matrix components, specifical ly col lagen II, glycosaminoglycans and proteoglycans, and reduces necrosis and apoptosis of chondrocytes. Chondroitin Sulfate also reduces the activity of collagenase, Nacetylglucosaminidase, aggrecanase 1 and 2, matrix metalloproteinase (MMP) 3, MMP-9, MMP-13, MMP-14, cathepsin B and elastase and elicits an anti-inflammatory effect through diverse mechanisms.