Arynoin Softgel Capsules 20Mg (1 Strip = 10 Capsules)

What is Arynoin 20mg?

Arynoin is a soft gelatin capsule containing Isotretinoin, a systemic retinoid prescribed for severe forms of acne — including nodular acne, conglobate acne, and acne at risk of permanent scarring — that hasn't responded to standard antibiotic or topical treatments. It works by suppressing sebaceous gland activity and reducing gland size, alongside a dermal anti-inflammatory effect.

Arynoin is a prescription-only medicine and must be used strictly under dermatologist supervision. It is not suitable for self-medication.

Composition & Product Details

How Does Arynoin Work?

Isotretinoin is a stereoisomer of all-trans retinoic acid. While its full mechanism isn't completely understood, clinical evidence shows the improvement seen in severe acne is linked to suppression of sebaceous gland activity and a measurable reduction in gland size, combined with an anti-inflammatory effect on the skin.

Who Is Arynoin For?

• Patients with severe nodular or conglobate acne
• Acne that hasn't responded to systemic antibiotics or topical therapy
• Cases at risk of permanent scarring without intervention
• Only under the direct care of a dermatologist experienced in retinoid therapy

Dosage & Administration

(For reference only — dosing must be determined and adjusted by your prescribing dermatologist)

• Treatment typically starts at 0.5 mg/kg/day, with most patients maintained at 0.5–1.0 mg/kg/day
• Severe cases may require up to 2.0 mg/kg/day
• Capsules are taken with food, once or twice daily
• A typical course runs 16–24 weeks, with a cumulative target dose of 120–150 mg/kg
• Remission is common after one full course; relapse may require a repeat course as advised by your dermatologist
• Patients with renal impairment usually start at a lower dose under closer supervision

Important Safety Information

Arynoin Is Contraindicated In

• Women who are pregnant, breastfeeding, or of childbearing potential without effective contraception
• Patients on tetracycline antibiotics
• Patients with hepatic insufficiency
• Patients with pre-existing hypervitaminosis A
• Patients with elevated blood lipid levels
• Anyone with known hypersensitivity to isotretinoin

Pregnancy Warning — Read Before Starting

Isotretinoin is teratogenic and pregnancy must be strictly avoided during treatment. Female patients of childbearing potential must:

• Use effective contraception for 1 month before, during, and after treatment
• Confirm a negative pregnancy test before starting
• Begin therapy on the 2nd or 3rd day of their menstrual cycle
• Never take Arynoin if pregnant or planning pregnancy

Monitoring Required

• Regular liver function tests throughout treatment
• Periodic lipid panel monitoring (elevated triglycerides can be linked to pancreatitis risk)
• Report any mood changes, unusual sadness, or psychological symptoms to your dermatologist immediately — rare cases of depression and mood changes have been associated with isotretinoin

Other Possible Effects

• Initial acne flare-up in the first 7–10 days, which usually subsides
• Dry skin, dry eyes, and increased sun sensitivity — avoid prolonged sun exposure
• Joint or muscle aches (myalgia/arthralgia) in some patients
• Rare reports of benign intracranial hypertension

Frequently Asked Questions

Do I need a prescription to buy Arynoin 20mg?

Yes. Isotretinoin is strictly prescription-only in Pakistan and requires dermatologist supervision throughout treatment.

Is it safe to take Arynoin during pregnancy?

No. Isotretinoin is absolutely contraindicated during pregnancy due to serious birth defect risks. Effective contraception is required before, during, and for one month after treatment.

How long does a typical Arynoin treatment course last?

Most courses run 16–24 weeks, depending on your dermatologist's assessment and your response to treatment.

What tests will I need during treatment?

Your dermatologist will typically order liver function tests and lipid panel monitoring at intervals throughout the course.

Can Arynoin cause mood changes?

Rare reports of depression and mood changes have been linked to isotretinoin. Report any such symptoms to your prescribing doctor right away.

Where can I buy Arynoin 20mg in Pakistan?

Arynoin is available at PillBox+ with a valid prescription, with delivery across Pakistan.