Eperisone HCl Used For Muscle Relaxant.

How it works

1.Skeletal muscle relaxation(1) Inhibition of experimentally-induced muscle rigidity Eperisone hydrochloride suppresses intercollicular section-induced decerebrate rigidity (?-rigidity) and ischemic decerebrate rigidity (a-rigidity) in rats dose-dependently. (2) Suppression of spinal reflexes In spinal cats, eperisone hydrochloride suppresses mono and poly-synaptic reflex potentials induced through spinal nerve efferent root stimulation to a similar degree. (3) Reduction of muscle spindle sensitivity via ?-motor neurons Eperisone hydrochloride suppresses the activity of afferent nerve fibers (Ia fibers) from human muscle spindles at 20 min after administration. Eperisone hydrochloride suppresses the spontaneous discharge of ?-motor neurons, but does not act directly on muscle spindles in animals. Accordingly, eperisone hydrochloride reduces muscle spindle sensitivity via the ?-motor neurons.