Levodopa , Carbidopa , Entacapone Used For Anti-Parkinson

How it works

Levodopa: The symptoms of Parkinson’s disease are related to depletion of dopamine in the corpus striatum. Levodopa, the metabolic precursor of dopamine, crosses the blood brain barrier and relieves the symptoms of the disease. Carbidopa: When levodopa is administered orally, it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. Carbidopa inhibits the decarboxylation of peripheral levodopa, making more levodopa available for delivery to the brain. Entacapone: Entacapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). When decarboxylation of levodopa is prevented by carbidopa, COMT becomes the major metabolizing enzyme for levodopa, catalyzing its metabolism to 3-methoxy-4-hydroxy-L-phenylalanine (3-OMD).