Restiro Tablets 80Mg (1 Box = 10 Tablets)
Regular price
Rs.1,425.00 PKR
Sale price
Rs.1,425.00 PKR
Regular price
Rs.1,500.00 PKR
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per
SKU: 108526
Category:
Generics
Resmetirom
Used For
Liver Disorder
How it works
Resmetirom is a partial agonist of the thyroid hormone receptor-beta (THR-β). Resmetirom produced 83.8% of the maximum response compared to triiodothyronine (T3), with an EC50 of 0.21 µM in an in vitro functional assay for THR-β activation. The same functional assay for thyroid hormone receptor-alpha (THR-α) agonism showed 48.6% efficacy for Resmetirom relative to T3, with an EC50 of 3.74 µM. THR-β is the major form of THR in the liver, and stimulation of THR-β in the liver reduces intrahepatic triglycerides, whereas actions of thyroid hormone outside the liver, including in heart and bone, are largely mediated through THR-α.